A COMPARATIV E , DOUBLE -BLIND, RANDOMIZE D, PLACEBO- CONTROLLED TRIAL OF INTRAPERITONEAL ADMINISTRATION OF BUPIVACAINE AND LIDOCAINE FOR PAIN CONTROL AFTER DIAGNOSTIC LAPARO SCOPY

The purpose of this study was to compare the effect of intraperitoneal bupivacaine and lidocaine administration on pain reduction after diagnostic laparoscopy. In this randomized, double blind, placebo controlled study, diagnostic laparoscopy was done for one-hundred and ninety-six infertile women with unexplained infertility. Patients were randomized to 4 groups (A, B,C, and D). At the end of the procedure, 30 mL of 0.125% bupivacaine, 30 mL of 5% lidocaine and 30 mL of normal saline was instilled in the pelvic cavity and 15 mL of the same solution over the diaphragmatic vault in group A, B and C, respectively. Group D received no intraperitoneal substance. The verbal pain scale questionnaire was used for assessment of postoperative pain. In conclusion, when instilled intraperitoneally after diagnostic laparoscopy, bupivacaine significantly decreases postoperative pain for a long period. It also reduces the rate of analgesic needed, increases the rate at which patients were discharged 2 hours after surgery, and decreases hospital stay. It is highly effective compared to lidocaine and placebo.